Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury

Nidia de Sousa; Diego Robledo; Laura González-Llera; Andreia G Pinho; Diogo J Santos; Susana Monteiro; Jonas Campos; Jorge R Cibrão; Nuno A Silva; Laura Sánchez; António J Salgado; Antón Barreiro-Iglesias

doi:10.1016/j.dib.2022.108809

Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury

Data Brief. 2022 Dec 7:46:108809. doi: 10.1016/j.dib.2022.108809. eCollection 2023 Feb.

Authors

Nidia de Sousa^{1

2}, Diego Robledo³, Laura González-Llera⁴, Andreia G Pinho^{1

2}, Diogo J Santos^{1

2}, Susana Monteiro^{1

2}, Jonas Campos^{1

2}, Jorge R Cibrão^{1

2}, Nuno A Silva^{1

2}, Laura Sánchez^{5

6}, António J Salgado^{1

2}, Antón Barreiro-Iglesias⁴

Affiliations

¹ ICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal.
² School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, Portugal.
³ The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK.
⁴ Department of Functional Biology, Faculty of Biology, CIBUS, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
⁵ Department of Zoology, Genetics and Physical Anthropology, Faculty of Veterinary Science, Universidade de Santiago de Compostela, Lugo 27002, Spain.
⁶ Preclinical Animal Models Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela 15706, Spain.

Abstract

Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments to promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can promote functional recovery after a compression SCI in mice [1]. Here, we provide transcriptomic (RNA-seq) data from adult mouse spinal cords collected 7 days after a compression SCI and baclofen (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used to generate the raw transcriptomic data. In addition, we also present bioinformatic analyses including differential gene expression analysis, enrichment analyses for various functional annotations (gene ontology, KEGG and BioCarta pathways or InterPro domains) and transcription factor targets. The raw RNA-seq data has been uploaded to the NCBI Sequence Read Archive (SRA) database (Bioproject ID PRJNA886048). The data generated from the bioinformatic analyses is contained within the article.

Keywords: Baclofen; Neuroprotection; RNA-seq; Regeneration; Spinal cord injury; Traumatic nervous system injury.