Trends in the contributions of atopic family history to pediatric food sensitization and allergy

Heping Fang; Zhuoying Ma; Lin Chen; Ruoling Xian; Juan Wang; Jing Chen; Haiqi Li; Yan Hu

doi:10.3389/fped.2022.967930

Trends in the contributions of atopic family history to pediatric food sensitization and allergy

Front Pediatr. 2022 Dec 7:10:967930. doi: 10.3389/fped.2022.967930. eCollection 2022.

Authors

Heping Fang¹, Zhuoying Ma¹, Lin Chen¹, Ruoling Xian¹, Juan Wang¹, Jing Chen¹, Haiqi Li¹, Yan Hu¹

Affiliation

¹ Department of Child Health Care, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China.

Abstract

Objective: Family history of atopic diseases (FHA) contributes to food allergy (FA). But little is known whether FHA primarily increases IgE-mediated, non-IgE-mediated FA, or both. And the trends in the contributions of FHA to food sensitization (FS) and FA remain unclear. We aim to clarify the associations among FHA, FS and FA and to understand the trends in the contributions of FHA to FS and FA.

Methods: We used chi-square test and mediating effect model to analyze the associations among FHA, FS and FA through comparisons between two cross-sectional investigations on FA in children under 2 years old in 2009 and 2019.

Results: In 2009 and 2019, the positive FHA proportion tended to be increasing without significance (28.9% to 31.6%, P = 0.39). Subgroup analysis showed the FS rate in FA group decreased significantly (37/39 to 44/62, P = 0.003). In 2009, the FS rate and FA prevalence were higher in FHA (+) group than in FHA (-) group (26% vs. 14.7%, P = 0.008 and 15% vs. 7.7%, P = 0.03), and FS had a complete mediating effect on the association between FHA and FA (Z = 2.54, P = 0.011), but the results lost significance in 2019.

Conclusions: The association between FHA and FA was completely mediated by FS, which means FHA mainly increases IgE-mediated FA. And the contributions of FHA to FS and FA tended to be stabilized or even diminished, which means FHA alone could no longer be enough to screen high-risk children.

Keywords: children; family history of atopic diseases (FHA); food allergy (FA); food sensitization (FS); trends.