Prokaryotic ncRNAs: Master regulators of gene expression

Rajib Majumder; Sanmitra Ghosh; Arpita Das; Manoj Kumar Singh; Saikat Samanta; Abinit Saha; Rudra P Saha

doi:10.1016/j.crphar.2022.100136

Prokaryotic ncRNAs: Master regulators of gene expression

Curr Res Pharmacol Drug Discov. 2022 Oct 17:3:100136. doi: 10.1016/j.crphar.2022.100136. eCollection 2022.

Authors

Rajib Majumder¹, Sanmitra Ghosh², Arpita Das¹, Manoj Kumar Singh¹, Saikat Samanta¹, Abinit Saha¹, Rudra P Saha¹

Affiliations

¹ Department of Biotechnology, School of Life Science & Biotechnology, Adamas University, Kolkata, 700126, India.
² Department of Biological Sciences, School of Life Science & Biotechnology, Adamas University, Kolkata, 700126, India.

Abstract

ncRNA plays a very pivotal role in various biological activities ranging from gene regulation to controlling important developmental networks. It is imperative to note that this small molecule is not only present in all three domains of cellular life, but is an important modulator of gene regulation too in all these domains. In this review, we discussed various aspects of ncRNA biology, especially their role in bacteria. The last two decades of scientific research have proved that this molecule plays an important role in the modulation of various regulatory pathways in bacteria including the adaptive immune system and gene regulation. It is also very surprising to note that this small molecule is also employed in various processes related to the pathogenicity of virulent microorganisms.

Keywords: Bacterial ncRNA; CRISPR; Gene regulation; Prokaryotic ncRNA; ncRNA; ncRNA biology.