Phytochemical screening, quantitative analysis of cyanidin-3-O-glucoside content, and anticancer activity of novel rice bran (Tubtim Chumphae rice)

Rittipun Rungruang; Napassorn Peasura; Nattapon Kaisangsri

doi:10.4103/japtr.japtr_458_22

Phytochemical screening, quantitative analysis of cyanidin-3-O-glucoside content, and anticancer activity of novel rice bran (Tubtim Chumphae rice)

J Adv Pharm Technol Res. 2022 Oct-Dec;13(4):312-316. doi: 10.4103/japtr.japtr_458_22. Epub 2022 Oct 10.

Authors

Rittipun Rungruang¹, Napassorn Peasura², Nattapon Kaisangsri³

Affiliations

¹ Department of Cosmetic Science, Faculty of Science and Technology, Suan Dusit University, Nakhon Pathom, Thailand.
² Agricultural and Functional Food Processing (AFP), Pilot Plant Development and Training Institute, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
³ Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.

Abstract

The objective of this research was to explore the phytochemicals in Tubtim Chumphae rice bran and determine their potential antioxidant and anticancer activities. The rice bran extract contained total phenolics, flavonoids, and anthocyanins as the major compounds. In addition, it exhibited the highest DPPH^•, followed by ABTS^•+, and FRAP radical scavenging activity. Moreover, the cytotoxic effect of the extract on Hep G2, SW620, KATO-III, BT474, and ChaGo-K-1 cancer cell lines was investigated; the obtained IC₅₀ values were 144.6 ± 0.39, 116.9 ± 0.68, 99.6 ± 0.10, 94.4 ± 0.33, and 25.6 ± 0.45 μg/mL, respectively. Overall, the abovementioned results suggest that rice bran extract has potent anticancer activity owing to the induction of cell death in cancer cell lines.

Keywords: Anticancer; cyanidin-3-O-glucoside; rice bran extract (Tubtim Chumphae rice).