Anabasis articulata exerts an anti-arthritic effect on adjuvant-induced arthritis in rats

Zaid Hamzah Abdulhusain; Makarim A Mahdi; Waleed K Abdulsahib; Layth S Jasim

doi:10.4103/japtr.japtr_440_22

Anabasis articulata exerts an anti-arthritic effect on adjuvant-induced arthritis in rats

J Adv Pharm Technol Res. 2022 Oct-Dec;13(4):276-280. doi: 10.4103/japtr.japtr_440_22. Epub 2022 Oct 10.

Authors

Zaid Hamzah Abdulhusain¹, Makarim A Mahdi², Waleed K Abdulsahib³, Layth S Jasim²

Affiliations

¹ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Al-Qadisiyah, Al Diwaniyah, Iraq.
² Department of Chemistry, College of Education, University of Al-Qadisiyah, Al Diwaniyah, Iraq.
³ Department of Pharmacology and Toxicology, College of Pharmacy, Al Farahidi University, Baghdad, Iraq.

Abstract

Anabasis articulata (AA) is commonly found in the Iraqi desert and is utilized in traditional medicine to cure kidney infections, eczema, fever, and diabetes. The paper aimed to identify the anti-arthritic impact of AA on arthritis models in rats. Complete Freund's Adjuvant (CFA) was used intradermally (ID) for the induction of arthritis. The author classified animals into four groups randomly: The first group took normal saline (control), the second group received AA orally for 14 days before induction and continue 17 days after induction, the third group was induced by CFA and received normal saline orally (model group), and the fourth group took AA orally 17 days after induction. AA administration increased body weight (BW) but decreased arthritis index (AI), histopathological scores, and vascular endothelial growth factor expression in synovial cells. AA has an important antiangiogenesis and anti-arthritic activity in arthritis model rats.

Keywords: Anabasis articulate; Arthritis; adjuvant-induced arthritis; vascular endothelial growth factor.