Tissue-Engineered Constructions in Biophysics, Neurology and Other Fields and Branches of Medicine

V P Reutov; L A Davydova; E G Sorokina

doi:10.1134/S0006350922050141

Tissue-Engineered Constructions in Biophysics, Neurology and Other Fields and Branches of Medicine

Biophysics (Oxf). 2022;67(5):816-834. doi: 10.1134/S0006350922050141. Epub 2022 Dec 19.

Authors

V P Reutov¹, L A Davydova², E G Sorokina³

Affiliations

¹ Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.
² Belarusian State Medical University, 220116 Minsk, Belarus.
³ National Medical Research Center for Children's Health of the Ministry of Health of the Russian Federation, 119991 Moscow, Russia.

Abstract

This paper describes the gangliopexy method, a method for creating a new center of local neurohumoral regulation, based on the formation of new connections discovered between the nervous system and the vascular system. The prospects for the development of this method are studied. At the same time, novel concepts about the cycles of nitric oxide and the superoxide anion radical are introduced. A possible role of these cycles is examined in the protection of cells and the body as a whole against oxidative and nitrosative stress, which develops when (in 5-30% of cases) destructive changes in the displaced ganglion lead to vascular complications and an increased risk of mortality. Mechanisms that can protect nerve cells, prevent the development of destructive changes in these cells and reduce the risk of mortality are also investigated.

Keywords: angiogenesis; cellular technologies; cyclicity principle and holographic principle; gangliopexy; nitrates; nitric oxide; nitric oxide and superoxide anion radical cycles; nitrites.

© Pleiades Publishing, Inc. 2022, ISSN 0006-3509, Biophysics, 2022, Vol. 67, No. 5, pp. 816–834. © Pleiades Publishing, Inc., 2022.Russian Text © The Author(s), 2022, published in Biofizika, 2022, Vol. 67, No. 5, pp. 1021–1041.