Rifampin-induced acute kidney injury and hemolysis: A case report and literature review of a rare condition

Fateen Ata; Hiba M B Magboul; Haneen A A Toba; Hadeel Alfar; Adel Al Bozom; Khaled Murshed; Muhammad Zahid

doi:10.1002/ccr3.6780

Rifampin-induced acute kidney injury and hemolysis: A case report and literature review of a rare condition

Clin Case Rep. 2022 Dec 21;10(12):e6780. doi: 10.1002/ccr3.6780. eCollection 2022 Dec.

Authors

Fateen Ata¹, Hiba M B Magboul², Haneen A A Toba², Hadeel Alfar², Adel Al Bozom², Khaled Murshed³, Muhammad Zahid^{2

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Affiliations

¹ Department of Endocrinology Hamad Medical Corporation Doha Qatar.
² Department of Internal Medicine Hamad Medical Corporation Doha Qatar.
³ Department of Anatomic Pathology Hamad Medical Corporation Doha Qatar.
⁴ Weill Cornell Medicine Doha Qatar.
⁵ College of Medicine Qatar University Doha Qatar.

Abstract

Rifampicin is a bactericidal drug used in various infectious diseases, including tuberculosis (TB). Nephrotoxicity is a rare side effect of intermittent Rifampin use and even less commonly continued use. We report a case of Rifampin-induced acute tubular necrosis and hemolysis in a patient with latent TB with a relevant literature review.

Keywords: acute interstitial nephritis; acute kidney injury; acute tubular necrosis; rifampicin; rifampin.

Publication types

Case Reports