Co-crystal nanoarchitectonics as an emerging strategy in attenuating cancer: Fundamentals and applications

Popat Kumbhar; Kaustubh Kolekar; Chinmayee Khot; Swati Dabhole; Ahmad Salawi; Fahad Y Sabei; Akshay Mohite; Kapil Kole; Susmit Mhatre; Niraj Kumar Jha; Arehalli Manjappa; Sachin Kumar Singh; Kamal Dua; John Disouza; Vandana Patravale

doi:10.1016/j.jconrel.2022.12.042

Co-crystal nanoarchitectonics as an emerging strategy in attenuating cancer: Fundamentals and applications

J Control Release. 2023 Jan:353:1150-1170. doi: 10.1016/j.jconrel.2022.12.042. Epub 2022 Dec 26.

Authors

Affiliations

¹ Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur, Maharashtra 416113, India.
² Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
³ Department of Pharmacy Sciences, School of Pharmacy and Health Professionals, Creighton University, Omaha, NE 68178, USA.
⁴ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, 201310, Uttar Pradesh, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India.
⁵ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
⁶ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, India.
⁷ Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur, Maharashtra 416113, India. Electronic address: jidisouza@tkcpwarana.ac.in.
⁸ Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, Maharashtra 400019, India. Electronic address: vb.patravale@ictmumbai.edu.in.

PMID: 36566843
DOI: 10.1016/j.jconrel.2022.12.042

Abstract

Cancer ranks as the second foremost cause of death in various corners of the globe. The clinical uses of assorted anticancer therapeutics have been limited owing to the poor physicochemical attributes, pharmacokinetic performance, and lethal toxicities. Various sorts of co-crystals or nano co-crystals or co-crystals-laden nanocarriers have presented great promise in targeting cancer via improved physicochemical attributes, pharmacokinetic performance, and reduced toxicities. These systems have also demonstrated the controlled cargo release and passive targeting via enhanced permeation and retention (EPR) effect. In addition, regional delivery of co-crystals via inhalation and transdermal route displayed remarkable potential in targeting lung and skin cancer effectively. However, more research is required on the use of co-crystals in cancer and their commercialization. The present review mainly emphasizes co-crystals as emerging avenues in the treatment of various cancers by modulating the physicochemical and pharmacokinetic attributes of approved anticancer therapeutics. The worth of co-crystals in cancer treatment, computational paths in the co-crystals screening, diverse experimental techniques of co-crystals fabrication, and sorts of co-crystals and their noteworthy applications in targeting cancer are also discussed. Besides, the game changer approaches like nano co-crystals and co-crystals-laden nanocarriers, and co-crystals in regional delivery in cancer are also explained with reported case studies. Furthermore, regulatory directives for pharmaceutical co-crystals and their scale-up, and challenges are also highlighted with concluding remarks and future initiatives. In essence, co-crystals and nano co-crystals emerge to be a promising strategy in overwhelming cancers through improving anticancer efficacy, safety, patient compliance, and reducing the cost.

Keywords: Biopharmaceutical properties; Cancer; Co-crystals; Localized delivery; Nano co-crystals; Nanocarriers; Scale-up.

Publication types

Review

MeSH terms

Drug Carriers
Drug Delivery Systems* / methods
Humans
Skin Neoplasms*

Substances

Drug Carriers