Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma: focus on immunohistochemical profile and association with Epstein-Barr virus

Francesca Pagliuca; Andrea Ronchi; Annamaria Auricchio; Eva Lieto; Renato Franco

doi:10.1186/s13027-022-00474-8

Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma: focus on immunohistochemical profile and association with Epstein-Barr virus

Infect Agent Cancer. 2022 Dec 24;17(1):63. doi: 10.1186/s13027-022-00474-8.

Authors

Francesca Pagliuca¹, Andrea Ronchi¹, Annamaria Auricchio², Eva Lieto², Renato Franco³

Affiliations

¹ Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Via Luciano Armanni 5, 80100, Naples, Italy.
² Division of Gastrointestinal Tract Surgical Oncology, Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', 80138, Naples, Italy.
³ Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Via Luciano Armanni 5, 80100, Naples, Italy. renato.franco@unicampania.it.

Abstract

Inflammatory pseudotumour-like follicular/fibroblastic dendritic cell sarcoma (IPT-like FDCS) is a rare EBV-associated variant of follicular dendritic cell sarcoma, usually arising in the liver or spleen and characterized by a favourable prognosis. The neoplastic cells show variable follicular dendritic cell or fibroblastic reticular cell differentiation and their immunoprofile is still poorly characterized. We describe a case of splenic IPT-like FDCS with unexpected CD31 expression and provide a concise review of English literature on the topic.

Keywords: Epstein-Barr virus; Immunohistochemistry; Inflammatory pseudotumour-like follicular/fibroblastic dendritic cell sarcoma.

Publication types

Review