Unexplained recurrent pregnancy loss: Novel causes and advanced treatment

Na Yu; Joanne Kwak-Kim; Shihua Bao

doi:10.1016/j.jri.2022.103785

Unexplained recurrent pregnancy loss: Novel causes and advanced treatment

J Reprod Immunol. 2023 Feb:155:103785. doi: 10.1016/j.jri.2022.103785. Epub 2022 Dec 19.

Authors

Na Yu¹, Joanne Kwak-Kim², Shihua Bao³

Affiliations

¹ Department of Reproductive Immunology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
² Reproductive Medicine and Immunology, Department of Obstetrics and Gynecology, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL 60061, USA.
³ Department of Reproductive Immunology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: baoshihua@tongji.edu.cn.

PMID: 36565611
DOI: 10.1016/j.jri.2022.103785

Abstract

In this study, recent research focusing on recurrent pregnancy loss (RPL) are reviewed. Recurrent pregnancy loss is a devastating reproductive health burden that affects about 5% of couples trying to conceive globally. Currently, there are few evidence-based diagnostic and treatment strategies for RPL. More so, the number of unexplained etiology cases in patients with RPL arrives at 50%. Here, we discuss the progress in diagnosis and treatment of unexplained RPL, as well as recommended treatment strategies and controversial etiologies.

Keywords: Etiology; Evidence-based medicine; Treatment strategy; Unexplained recurrent pregnancy loss.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Habitual* / diagnosis
Abortion, Habitual* / therapy
Female
Humans
Pregnancy