Effect of d-β-Hydroxybutyrate-(R)-1,3 Butanediol on Appetite Regulation in People with Prediabetes

Mol Nutr Food Res. 2023 Feb;67(4):e2200615. doi: 10.1002/mnfr.202200615. Epub 2023 Jan 26.

Abstract

Scope: The main aim of the present study is to study the effect of acute ketosis on parameters of appetite regulation in prediabetes.

Methods and results: This is a randomized controlled trial registered under ClinicalTrials.gov identifier NCT03889210. After an overnight fast, 18 adults with prediabetes are assigned to consume a ketone monoester (d-β-hydroxybutyrate-(R)-1,3 butanediol) drink and a placebo drink in cross-over fashion. Blood samples are collected every 30 min, from baseline to 150 min. Paired t test is used to compare the total area under the curve (AUC) for the changes in parameters of appetite regulation (acylated ghrelin, peptide YY [PYY], and hunger) following both drinks. Significant elevation in blood β-hydroxybutyrate from 0.2 to 3.5 mmol L-1 (p < 0.001) is achieved within 30 min. Acute ketosis does not result in statistically significant differences in the AUCs for ghrelin, PYY, and hunger.

Conclusion: Acute ketosis consistently does not affect both objective and subjective parameters of appetite regulation in prediabetes.

Keywords: appetite; eating behavior; ketosis; prediabetes.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Hydroxybutyric Acid
  • Adult
  • Appetite
  • Appetite Regulation
  • Ghrelin
  • Humans
  • Ketosis*
  • Peptide YY
  • Prediabetic State*

Substances

  • Ghrelin
  • 3-Hydroxybutyric Acid
  • Peptide YY

Associated data

  • ClinicalTrials.gov/NCT03889210