Finding optimal drug target sites in parasite pathogens

Abstract

Benns et al. have recently combined a chemoproteomic profiling method with a CRISPR-based gene-editing method to identify chemically targetable residues essential for fitness in the parasite Toxoplasma gondii. The result is a strategy that enables rapid discovery of new drug targets to combat T. gondii and other related parasites.

Keywords: CRISPR-mediated gene editing; Plasmodium falciparum; Toxoplasma gondii; activity-based protein profiling; chemoproteomics; cysteine reactivity.