The gymnastics of intraflagellar transport complexes keeps trains running inside cilia

Maxence V Nachury

doi:10.1016/j.cell.2022.12.005

The gymnastics of intraflagellar transport complexes keeps trains running inside cilia

Cell. 2022 Dec 22;185(26):4863-4865. doi: 10.1016/j.cell.2022.12.005.

Author

Maxence V Nachury¹

Affiliation

¹ Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: maxence.nachury@ucsf.edu.

PMID: 36563659
DOI: 10.1016/j.cell.2022.12.005

Abstract

The assembly and signaling properties of cilia rely on intraflagellar transport (IFT) trains moving proteins into, within, and out of cilia. A flurry of near-atomic models of the multiprotein complexes that make up IFT trains has revealed new conformational changes, which may underlie the switch between anterograde and retrograde intraflagellar transport.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biological Transport
Cilia* / metabolism
Flagella / metabolism
Gymnastics
Running*

Grants and funding

R01 GM089933/GM/NIGMS NIH HHS/United States