TRIM21‑a potential biomarker for the prognosis of thyroid cancer

Zhen Wu; Yongkun Wang; Zhengya Yu; Zhen Meng; Wenchao Duan; Wei Zhang; Jugao Fang

doi:10.3892/etm.2022.11697

TRIM21‑a potential biomarker for the prognosis of thyroid cancer

Exp Ther Med. 2022 Nov 9;24(6):761. doi: 10.3892/etm.2022.11697. eCollection 2022 Dec.

Authors

Zhen Wu^{1

2}, Yongkun Wang², Zhengya Yu¹, Zhen Meng³, Wenchao Duan⁴, Wei Zhang², Jugao Fang¹

Affiliations

¹ Department of Otorhinolaryngology Head and Neck Surgery and Department of Thyroid Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
² Department of Thyroid and Breast Surgery, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
³ Department of Stomatology, Medical School of Liaocheng University, Liaocheng, Shandong 252000, P.R. China.
⁴ Department of Otorhinolaryngology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Abstract

Thyroid cancer (THCA) is one of the commonest malignancies associated with increased recurrence. Therefore, identifying the putative molecular markers and therapeutic targets to improve the treatment of THCA is essential. The present study analyzed the potential role of tripartite motif-containing 21 (TRIM21), a member of the TRIM family belonging to the subfamily of E3 ubiquitin ligases, in the progression of THCA. Using bioinformatics analysis and immunohistochemistry of THCA tissues, it was observed that TRIM21 is overexpressed in THCA tissues. The present study also found that TRIM21 is associated with lymph node metastasis and high-risk recurrence of THCA. Furthermore, it identified a promotional role of TRIM21 in THCA cell migration and invasion. In addition, the present study analyzed TRIM21-enriched pathways and co-expressed genes in THCA. The present study suggested that TRIM21 may serve as a potential biomarker for THCA prognosis.

Keywords: bioinformatical analysis; clinicopathologic features; migration and invasion; thyroid cancer; tripartite motif-containing 21.

Grants and funding

Funding: The present study was supported by the Science and Technology Project of Shandong Society of Geriatrics (grant no. LKJGG2021W069), and the Medical and Health Science project of Shandong Province (grant no. 202104010413).