Salvage LATTICE radiotherapy for a growing tumour despite conventional radio chemotherapy treatment of lung cancer

Rémy Kinj; Alessio Casutt; Tu Nguyen-Ngoc; Ange Mampuya; Luis Schiappacasse; Jean Bourhis; Constance Huck; David Patin; Maud Marguet; Michele Zeverino; Raphaël Moeckli; Michel Gonzalez; Alban Lovis; Mahmut Ozsahin

doi:10.1016/j.ctro.2022.11.016

Salvage LATTICE radiotherapy for a growing tumour despite conventional radio chemotherapy treatment of lung cancer

Clin Transl Radiat Oncol. 2022 Dec 5:39:100557. doi: 10.1016/j.ctro.2022.11.016. eCollection 2023 Mar.

Authors

Affiliations

¹ Department of Radiation Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
² Department of Pulmonology, Lausanne University Hospital (CHUV) and Lausanne University (UNIL), Lausanne, Switzerland.
³ Department of Medical Oncology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
⁴ Institute of Radiation Physics, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
⁵ Department of Thoracic Surgery, University Hospital Center of Lausanne (CHUV), and University of Lausanne (UNIL), Lausanne, Switzerland.

Abstract

A 40-year-old patient with cT4cN1M0 squamous cell lung cancer of the upper right lobe received preoperative induction chemotherapy. Systemic induction treatment failed to reverse tumour growth with the addition of conventional radiotherapy (RT). A salvage lattice RT boost of 12 Gy was administered immediately to increase the dose to the tumour. Conventional RT was resumed at the planned dose of 60 Gy. The tumour shrank rapidly, and the patient was surged. The postoperative pathology remained ypT0ypN0 status.

Keywords: IGRT, image-guided RT; Immunotherapy; LRT, lattice RT; Lattice boost; Lattice radiotherapy; Lung cancer; NSCLC, non small-cell lung cancer; RT, Radiotherapy; SFRT, spatially fractionnated RT; Spatially fractionated radiotherapy.

Publication types

Case Reports