Slightly Elevated Lymphocyte to Monocyte Ratio Predicting Favorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage

Jinjin Wang; Wenjuan Wang; Anxin Wang; Xiaoli Zhang; Liheng Bian; Yang Du; Jingjing Lu; Xingquan Zhao

doi:10.2147/JIR.S390557

Slightly Elevated Lymphocyte to Monocyte Ratio Predicting Favorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage

J Inflamm Res. 2022 Dec 16:15:6773-6783. doi: 10.2147/JIR.S390557. eCollection 2022.

Authors

Jinjin Wang^#^{1

2}, Wenjuan Wang^#^{1

2}, Anxin Wang^{1

2}, Xiaoli Zhang^{1

2}, Liheng Bian^{1

2}, Yang Du^{1

2}, Jingjing Lu^{1

2}, Xingquan Zhao^{1

2

3

4}

Affiliations

¹ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
² China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China.
³ Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
⁴ Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People's Republic of China.

^# Contributed equally.

Abstract

Objective: This study was designed to determine the association between admission lymphocyte to monocyte ratio (LMR) values and clinical outcomes in patients with spontaneous intracerebral hemorrhage (ICH).

Methods: We used a prospective and registry-based database, and ICH patients were consecutively recruited in Beijing Tiantan Hospital between January 2014 and September 2016. All participants were stratified by quartiles of the LMR. Univariable and multivariable logistic regression analyses were plotted to evaluate the association between LMR levels and functional outcomes. Kaplan-Meier survival curves and Cox regression analysis were also performed to examine the relevance between different LMR quartiles and case fatality at follow-up.

Results: Six hundred and forty patients with spontaneous ICH were finally included in this study. Compared with the patients with LMR values in quartile 1 (Q1), slightly elevated LMR values showed a negative correlation with risks of poor short-term outcomes (adjusted ORs in Q2 were 0.572 [95% CI: 0.338-0.968] at 1 month, 0.515 [95% CI: 0.305-0.871] at 3 months). Patients with LMR values in Q1 had the highest cumulative death rate. A slightly elevated LMR was also independently relevant to a deduced mortality rate compared to that in Q1 (adjusted HRs in Q2 were 0.471 [95% CI: 0.274-0.809] at 1 month, 0.474 [95% CI: 0.283-0.793] at 3 months, 0.575 [95% CI: 0.361-0.917] at 1 year). Additionally, a higher LMR value was associated with a lower risk of in-hospital infections.

Conclusion: This study suggests that a lower LMR value is associated with higher risks of in-hospital infections, poor functional outcomes, and follow-up mortality in patients with ICH. However, a slightly elevated LMR value, especially in Q2, relates to a favorable prognosis, which may reflect an inner balance between inflammation and immunodepression and thus provides a promising marker for predicting ICH prognosis.

Keywords: in-hospital infections; lymphocyte to monocyte ratio; outcomes; spontaneous intracerebral hemorrhage.

Grants and funding

The research was supported by the National Key Research and Development Program of the People’s Republic of China (Grant No.2018YFC1312200/2018YFC131224 & 2018YFC1705003), CAMS Innovation Fund for Medical Sciences (2019-I2M-5-029) and Beijing Municipal Committee of Science and Technology (Z201100005620010).