Nonthermal Biocompatible Plasma Inactivation of Coronavirus SARS-CoV-2: Prospects for Future Antiviral Applications

Ihn Han; Sohail Mumtaz; Eun Ha Choi

doi:10.3390/v14122685

Nonthermal Biocompatible Plasma Inactivation of Coronavirus SARS-CoV-2: Prospects for Future Antiviral Applications

Viruses. 2022 Nov 30;14(12):2685. doi: 10.3390/v14122685.

Authors

Ihn Han^{1

2}, Sohail Mumtaz^{2

3}, Eun Ha Choi^{1

2}

Affiliations

¹ Department of Plasma Bio-Display, Kwangwoon University, Seoul 01897, Republic of Korea.
² Plasma Bioscience Research Center (PBRC), Applied Plasma Medicine Center, Kwangwoon University, Seoul 01897, Republic of Korea.
³ Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Republic of Korea.

Abstract

The coronavirus disease (COVID-19) pandemic has placed a massive impact on global civilization. Finding effective treatments and drugs for these viral diseases was crucial. This paper outlined and highlighted key elements of recent advances in nonthermal biocompatible plasma (NBP) technology for antiviral applications. We searched for papers on NBP virus inactivation in PubMed ePubs, Scopus, and Web of Science databases. The data and relevant information were gathered in order to establish a mechanism for NBP-based viral inactivation. NBP has been developed as a new, effective, and safe strategy for viral inactivation. NBP may be used to inactivate viruses in an ecologically friendly way as well as activate animal and plant viruses in a number of matrices. The reactive species have been shown to be the cause of viral inactivation. NBP-based disinfection techniques provide an interesting solution to many of the problems since they are simply deployable and do not require the resource-constrained consumables and reagents required for traditional decontamination treatments. Scientists are developing NBP technology solutions to assist the medical community in dealing with the present COVID-19 outbreak. NBP is predicted to be the most promising strategy for battling COVID-19 and other viruses in the future.

Keywords: COVID-19; NBP viral inactivation; SARS-CoV-2; coronavirus disinfection; nonthermal plasma.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / pharmacology
Antiviral Agents / therapeutic use
COVID-19*
Plant Viruses*
SARS-CoV-2
Virus Diseases* / drug therapy
Virus Inactivation

Substances

Antiviral Agents

Grants and funding

This work was supported by the National Research Foundation of Korea (NRF) with grants funded by the Basic Science Research Program through funding by the Ministry of Education (2020R1I1A1A01073071), the Korean government (MIST) [NRF-2022R1A2C1004257, NRF-2021R1A6A1A03038785].