Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation

Lu Yang; Hongwei Su; Yue Sun; Sen Zhang; Maosheng Cheng; Yongxiang Liu

doi:10.3390/molecules27248956

Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation

Molecules. 2022 Dec 15;27(24):8956. doi: 10.3390/molecules27248956.

Authors

Lu Yang^{1

2

3}, Hongwei Su^{1

3}, Yue Sun^{1

2

3}, Sen Zhang^{1

2

3}, Maosheng Cheng^{1

3}, Yongxiang Liu^{1

2

3}

Affiliations

¹ Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
² Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
³ Institute of Drug Research in Medicine Capital of China, Shenyang Pharmaceutical University, Benxi 117000, China.

Abstract

Gold catalysts possess the advantages of water and oxygen resistance, with the possibility of catalyzing many novel chemical transformations, especially in the syntheses of small-molecule skeletons, in addition to achieving the rapid construction of multiple chemical bonds and ring systems in one step. In this feature paper, we summarize recent advances in the construction of small-molecule scaffolds, such as benzene, cyclopentene, furan, and pyran, based on gold-catalyzed cyclization of arylalkyne derivatives within the last decade. We hope that this review will serve as a useful reference for chemists to apply gold-catalyzed strategies to the syntheses of related natural products and active molecules, hopefully providing useful guidance for the exploration of additional novel gold-catalyzed approaches.

Keywords: arylalkyne; benzene derivatives; cyclopentene derivatives; furan and pyran derivatives; gold(I)-catalyzed.

Publication types

Review

MeSH terms

Biological Products* / chemistry
Catalysis
Cyclization
Gold* / chemistry

Substances

Gold
Biological Products

Grants and funding

This research was funded by the National Natural Science Foundation of China (No. 21977073), the Foundation of Liaoning Province Education Administration (No. LJKZ0908 and No. LJKQZ2022236), the Liaoning Provincial Foundation of Natural Science (No. 2022-MS-245), and the China Postdoctoral Science Foundation (No. 2022MD723807).