Isolation and bioactivity of new tanshinones

A R Lee; W L Wu; W L Chang; H C Lin; M L King

doi:10.1021/np50050a004

Isolation and bioactivity of new tanshinones

J Nat Prod. 1987 Mar-Apr;50(2):157-60. doi: 10.1021/np50050a004.

Authors

A R Lee¹, W L Wu, W L Chang, H C Lin, M L King

Affiliation

¹ School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, R.O.C.

PMID: 3655791
DOI: 10.1021/np50050a004

Abstract

Two new diterpenoids, designated neocryptotanshinone and isotanshinone IIB, have been isolated from "Tan-Shen," the root of Salvia miltiorrhiza, together with a known compound, danshexinkun A. Their structures are established by spectral and physical data. Isotanshinone IIB exhibits significant inhibitory activity in vitro on ADP- and collagen-induced aggregation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abietanes
Adenosine Diphosphate / antagonists & inhibitors
Collagen / antagonists & inhibitors
Humans
In Vitro Techniques
Phenanthrenes / isolation & purification*
Phenanthrenes / pharmacology
Plants, Medicinal / analysis
Platelet Aggregation / drug effects*

Substances

Abietanes
Phenanthrenes
tanshinone
Adenosine Diphosphate
Collagen