Application of Deep Learning in Histopathology Images of Breast Cancer: A Review

Micromachines (Basel). 2022 Dec 11;13(12):2197. doi: 10.3390/mi13122197.

Abstract

With the development of artificial intelligence technology and computer hardware functions, deep learning algorithms have become a powerful auxiliary tool for medical image analysis. This study was an attempt to use statistical methods to analyze studies related to the detection, segmentation, and classification of breast cancer in pathological images. After an analysis of 107 articles on the application of deep learning to pathological images of breast cancer, this study is divided into three directions based on the types of results they report: detection, segmentation, and classification. We introduced and analyzed models that performed well in these three directions and summarized the related work from recent years. Based on the results obtained, the significant ability of deep learning in the application of breast cancer pathological images can be recognized. Furthermore, in the classification and detection of pathological images of breast cancer, the accuracy of deep learning algorithms has surpassed that of pathologists in certain circumstances. Our study provides a comprehensive review of the development of breast cancer pathological imaging-related research and provides reliable recommendations for the structure of deep learning network models in different application scenarios.

Keywords: breast cancer; deep learning; histopathology; pathological image.

Publication types

  • Review

Grants and funding

This research was funded by the Fundamental Research Funds for the Central Universities N2219001, Ningbo Science and Technology Bureau (Grant No.2021Z027) and the Fundamental Research Funds for the Central Universities N2224001-10.