Maternal and Dietary Factors Are Associated with Metabolic Syndrome in Women with a Previous History of Gestational Diabetes Mellitus

Int J Environ Res Public Health. 2022 Dec 14;19(24):16797. doi: 10.3390/ijerph192416797.

Abstract

While it is known that women with a previous history of gestational diabetes mellitus (post-GDM) have a higher risk of metabolic syndrome (MetS), evidence of lifestyle practices from low- and middle-income countries (LMICs) is still scarce. This study aimed to determine the factors associated with MetS in women post-GDM. This cross-sectional study involved 157 women post-GDM (mean age 34.8 ± 5.6 years) sampled from Selangor, Malaysia. We collected data on sociodemographic characteristics and obstetric history. Food intake was assessed using a food frequency questionnaire, and dietary patterns were derived from principal component analysis. MetS was diagnosed according to the 2009 Harmonized criteria. The prevalence of MetS in this study was 22.3%. Western dietary pattern consumption was correlated with MetS, body mass index (BMI), waist circumference, and triglyceride levels. Independent factors associated with MetS were lower education level (odds ratio, OR 4.017, p = 0.007), pre-pregnancy BMI (OR 1.192, p = 0.002), and Caesarean delivery (OR 3.798, p = 0.009). The study identified the maternal and dietary factors associated with MetS in women post-GDM in Malaysia. Community-based interventions that include dietary modification are warranted to prevent MetS and its complications, thus helping to reduce the overall disease burden.

Keywords: Malaysia; cardiometabolic risk; determinants; dietary patterns; gestational diabetes mellitus; low- and middle-income countries; metabolic syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Mass Index
  • Cross-Sectional Studies
  • Diabetes, Gestational* / epidemiology
  • Diabetes, Gestational* / prevention & control
  • Female
  • Humans
  • Malaysia / epidemiology
  • Metabolic Syndrome* / complications
  • Metabolic Syndrome* / epidemiology
  • Pregnancy
  • Risk Factors

Grants and funding

The Fundamental Research Grant Scheme under the Ministry of Higher Education Malaysia (FRGS/1/2018/SKK05/UPM/02/2, code 04-01-18-1974FR, vote 5540099) funded the study.