The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis

Xiaoxing Wang; Defa Huang; Jiyang Wu; Zhengzhe Li; Xiaomei Yi; Tianyu Zhong

doi:10.3390/cells11244071

The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis

Cells. 2022 Dec 15;11(24):4071. doi: 10.3390/cells11244071.

Authors

Xiaoxing Wang^{1

2}, Defa Huang^{1

2}, Jiyang Wu^{1

2}, Zhengzhe Li^{1

2}, Xiaomei Yi^{1

2}, Tianyu Zhong^{1

2}

Affiliations

¹ The First School of Clinical Medicine, Gannan Medical University, Ganzhou 341000, China.
² Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.

Abstract

Colorectal cancer (CRC) is a malignancy that seriously threatens human health, and metastasis from CRC is a major cause of death and poor prognosis for patients. Studying the potential mechanisms of small extracellular vesicles (sEVs) in tumor development may provide new options for early and effective diagnosis and treatment of CRC metastasis. In this review, we systematically describe how sEVs mediate epithelial mesenchymal transition (EMT), reconfigure the tumor microenvironment (TME), modulate the immune system, and alter vascular permeability and angiogenesis to promote CRC metastasis. We also discuss the current difficulties in studying sEVs and propose new ideas.

Keywords: angiogenesis; colorectal cancer; metastasis; small extracellular vesicles; tumor microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Colorectal Neoplasms* / pathology
Extracellular Vesicles* / pathology
Humans
Tumor Microenvironment

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant numbers 82260422), Key R&D Planning Project of Jiangxi Science and Technology Commission, China (No. 20203BBGL73126).