Mechanisms of RNA and Protein Quality Control and Their Roles in Cellular Senescence and Age-Related Diseases

Donghee Kang; Yurim Baek; Jae-Seon Lee

doi:10.3390/cells11244062

Mechanisms of RNA and Protein Quality Control and Their Roles in Cellular Senescence and Age-Related Diseases

Cells. 2022 Dec 15;11(24):4062. doi: 10.3390/cells11244062.

Authors

Donghee Kang^{1

2}, Yurim Baek^{1

2

3}, Jae-Seon Lee^{1

2

3}

Affiliations

¹ Research Center for Controlling Intercellular Communication (RCIC), College of Medicine, Inha University, Incheon 22212, Republic of Korea.
² Department of Molecular Medicine, College of Medicine, Inha University, Incheon 22212, Republic of Korea.
³ Program in Biomedical Science & Engineering, Inha University, Incheon 22212, Republic of Korea.

Abstract

Cellular senescence, a hallmark of aging, is defined as irreversible cell cycle arrest in response to various stimuli. It plays both beneficial and detrimental roles in cellular homeostasis and diseases. Quality control (QC) is important for the proper maintenance of cellular homeostasis. The QC machineries regulate the integrity of RNA and protein by repairing or degrading them, and are dysregulated during cellular senescence. QC dysfunction also contributes to multiple age-related diseases, including cancers and neurodegenerative, muscle, and cardiovascular diseases. In this review, we describe the characters of cellular senescence, discuss the major mechanisms of RNA and protein QC in cellular senescence and aging, and comprehensively describe the involvement of these QC machineries in age-related diseases. There are many open questions regarding RNA and protein QC in cellular senescence and aging. We believe that a better understanding of these topics could propel the development of new strategies for addressing age-related diseases.

Keywords: RNA quality control; age-related diseases; cellular senescence; protein quality control.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Cycle Checkpoints
Cellular Senescence* / genetics
Homeostasis
RNA*

Substances

RNA

Grants and funding

This work was supported by grants to J.-S.L. from RCIC (2021R1A5A2031612) and the Basic Research Science Program (2020R1A2B5B02002375) through the National Research Foundation (NRF) funded by the Korean Government (MSIT).