Alternative Geometries for 3D Bioprinting of Calcium Phosphate Cement as Bone Substitute

Jennifer Blankenburg; Johannes Vinke; Bianca Riedel; Sergej Zankovic; Hagen Schmal; Michael Seidenstuecker

doi:10.3390/biomedicines10123242

Alternative Geometries for 3D Bioprinting of Calcium Phosphate Cement as Bone Substitute

Biomedicines. 2022 Dec 13;10(12):3242. doi: 10.3390/biomedicines10123242.

Authors

Jennifer Blankenburg^{1

2}, Johannes Vinke², Bianca Riedel¹, Sergej Zankovic¹, Hagen Schmal¹, Michael Seidenstuecker¹

Affiliations

¹ G.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.
² Institute for Applied Biomechanics, Offenburg University, Badstraße 24, 77652 Offenburg, Germany.

Abstract

In the literature, many studies have described the 3D printing of ceramic-based scaffolds (e.g., printing with calcium phosphate cement) in the form of linear structures with layer rotations of 90°, although no right angles can be found in the human body. Therefore, this work focuses on the adaptation of biological shapes, including a layer rotation of only 1°. Sample shapes were printed with calcium phosphate cement using a 3D Bioplotter from EnvisionTec. Both straight and wavy spokes were printed in a round structure with 12 layers. Depending on the strand diameter (200 and 250 µm needle inner diameter) and strand arrangement, maximum failure loads of 444.86 ± 169.39 N for samples without subsequent setting in PBS up to 1280.88 ± 538.66 N after setting in PBS could be achieved.

Keywords: 3D printing; CDHA; CPC; bone replacement; calcium phosphate cement.

Grants and funding

The article processing charge was funded by the Baden-Wuerttemberg Ministry of Science, Research and Art and the University of Freiburg in the funding programme Open Access Publishing.