Rationale: TFEB-associated renal cell carcinoma is very rare and belongs to the microphthalmia - associated transcription family translocation renal cell carcinoma.
Patient concerns: Hospitalized for fever, a 29-year-old male patient had a left kidney lesion without any additional discomfort.
Diagnoses: Histopathological and immunohistochemical results were corresponding with TFEB renall cell carcinoma features.
Interventions: Surgical resection of the tumor was performed.
Outcomes: After 8 months of follow-up, no tumor recurrence was observed.
Lessons: TFEB-associated renal cell carcinoma is rare. The diagnosis is explicit. However, the optimal treatment needs to be further explored.
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