Tricholosterols A-D, four new ergosterol derivatives from the mushroom Tricholoma terreum

Steroids. 2023 Mar:191:109157. doi: 10.1016/j.steroids.2022.109157. Epub 2022 Dec 19.

Abstract

Four ergosterol derivatives, named tricholosterols A-D (1-4), have been isolated from the fruiting bodies of Tricholoma terreum. Their chemical structures have been determined using a combination of spectroscopic analysis as well as computational methods. Compound 1 possesses a rare D-ring opening ergosterol skeleton, while compounds 2-4 are rare degraded ergosterols. Compounds 1 and 4 exhibited moderate inhibitory activity against NO production with IC50 values of 27.6 and 31.8 μM, respectively. This is the first report of steroids from T. terreum.

Keywords: Ergosterol derivatives; NO production inhibition; Tricholoma terreum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ergosterol* / chemistry
  • Ergosterol* / isolation & purification
  • Ergosterol* / pharmacology
  • Fruiting Bodies, Fungal / chemistry
  • Nitric Oxide* / antagonists & inhibitors
  • Tricholoma* / chemistry
  • Tricholoma* / metabolism

Substances

  • Ergosterol
  • Nitric Oxide

Supplementary concepts

  • Tricholoma terreum