High-Resolution Splenic Imaging: [68Ga]Ga-Oxine Red Blood Cell PET/CT for Differentiation of Splenosis Mimicking Malignant Lymphoma

Tomography. 2022 Dec 12;8(6):2915-2918. doi: 10.3390/tomography8060244.

Abstract

The differentiation of splenic tissue from malignant lesions via imaging may be challenging, particularly considering aberrant or accessory lesions and diseases that are rarely encountered. Functioning splenic tissue can be identified using technetium-99m red blood cell (99mTc-RBC) scintigraphy, but its sensitivity is limited and may not be available. We present the case of a patient in whom disseminated abdomino-pelvic splenosis was diagnosed using PET/CT with gallium-68-oxine-labeled RBCs. The method represents a feasible and probably superior alternative to splenic scintigraphy.

Keywords: PET/CT; erythrocytes; oxine; oxyquinoline; radiotracers; spleen.

Publication types

  • Case Reports

MeSH terms

  • Cell Differentiation
  • Erythrocytes
  • Gallium Radioisotopes
  • Humans
  • Lymphoma*
  • Positron Emission Tomography Computed Tomography
  • Splenosis* / diagnostic imaging

Substances

  • Gallium Radioisotopes

Grants and funding

This research received no external funding.