E26 transformation specific or E twenty-six (ETS) protein family consists of 28 transcription factors, five of which, named ETS1/2, PU.1, ERG and EHF, are known to involve in the development of liver fibrosis, and are expected to become diagnostic markers or therapeutic targets of liver fibrosis. In recent years, some small molecule inhibitors of ETS protein family have been discovered, which might open up a new path for the liver fibrosis therapy targeting ETS. This article reviews the research progress of ETS family members in the development liver fibrosis as well as their prospect of clinical application.
Keywords: EHF; ERG; ETS transcription factors; ETS1; ETS2; Liver fibrosis; PU.1; Small-molecule inhibitor.
© 2022. The Author(s) under exclusive licence to Japan Human Cell Society.