Recent advances in bioactive nanocrystal-stabilized Pickering emulsions: Fabrication, characterization, and biological assessment

Dan Yang; Yuqi Feng; Xiaolin Yao; Baofu Zhao; Dan Li; Ning Liu; Yapeng Fang; Adam Midgley; Dechun Liu; Nishinari Katsuyoshi

doi:10.1111/1541-4337.13096

Recent advances in bioactive nanocrystal-stabilized Pickering emulsions: Fabrication, characterization, and biological assessment

Compr Rev Food Sci Food Saf. 2023 Mar;22(2):946-970. doi: 10.1111/1541-4337.13096. Epub 2022 Dec 22.

Authors

Dan Yang^{1

2}, Yuqi Feng^{1

2}, Xiaolin Yao^{1

2}, Baofu Zhao^{1

2}, Dan Li^{1

2}, Ning Liu^{1

2}, Yapeng Fang³, Adam Midgley⁴, Dechun Liu⁵, Nishinari Katsuyoshi⁶

Affiliations

¹ School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, China.
² School of Biomedical and Pharmaceutical Science, Shaanxi University of Science and Technology, Xi'an, Shaanxi, China.
³ Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
⁴ Key Laboratory of Bioactive Materials (MoE), College of Life Sciences, Nankai University, Tianjin, China.
⁵ Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
⁶ Glyn O. Phillips Hydrocolloid Research Centre, School of Bioengineering and Food Science, Hubei University of Technology, Wuhan, China.

PMID: 36546411
DOI: 10.1111/1541-4337.13096

Abstract

Numerous literatures have shown the advantages of Pickering emulsion (PE) for the delivery of bioactive ingredients in the fields of food, medicine, and cosmetics, among others. On this basis, the multi-loading mode of bioactives (internal phase encapsulation and/or loading at the interface) in small molecular bioactives nanocrystal-stabilized PE (BNC-PE) enables them higher loading efficiencies, controlled release, and synergistic or superimposed effects. Therefore, BNC-PE offers an efficacious delivery system. In this review, we briefly summarize BNC-PE fabrication and characterization, with a focus on the processes of possible evolution and absorption of differentially applied BNC-PE when interacting with the body. In addition, methods of monitoring changes and absorption of BNC-PE in vivo, from the nanomaterial perspective, are also introduced. The purpose of this review is to provide an accessible and comprehensive methodology for the characterization and evaluation of BNC-PE after formulation and preparation, especially in relation to biological assessment and detailed mechanisms throughout the absorption process of BNC-PE in vivo.

Keywords: Pickering emulsion; adsorption; bioactive compound; biological assessment; crystallization.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Emulsions
Nanoparticles*
Nanostructures*

Substances

Emulsions