Toward a molecular mechanism-based prediction of CRISPR-Cas9 targeting effects

Affiliations

• ¹ Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Shanghai Research Institute for Intelligent Autonomous Systems, Shanghai 201210, China.
• ² Department of Plastic and Reconstructive Surgery, Shanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: zhangchao@shsmu.edu.cn.
• ³ Roche Pharma Research and Early Development, pRED Informatics, Roche Innovation Center Shanghai, Roche R&D Center (China) Ltd., Shanghai 201203, China. Electronic address: qing.zhang@roche.com.
• ⁴ Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Shanghai Research Institute for Intelligent Autonomous Systems, Shanghai 201210, China. Electronic address: qiliu@tongji.edu.cn.