The effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway on organ inflammatory injury and fibrosis

Yuliang Liu; Yihui Li; Li Xue; Jie Xiao; Pengyong Li; Wanlin Xue; Chen Li; Haipeng Guo; Yuguo Chen

doi:10.3389/fphar.2022.1033982

The effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway on organ inflammatory injury and fibrosis

Front Pharmacol. 2022 Dec 5:13:1033982. doi: 10.3389/fphar.2022.1033982. eCollection 2022.

Authors

Yuliang Liu^{1

2

3}, Yihui Li^{1

2

3}, Li Xue^{2

3

4}, Jie Xiao^{1

2

3}, Pengyong Li^{1

2

3}, Wanlin Xue^{1

2

3}, Chen Li^{1

2

3}, Haipeng Guo^{1

2

3}, Yuguo Chen^{2

3

4}

Affiliations

¹ Department of Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
² The Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
³ The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
⁴ Department of Emergency Medicine and Chest Pain Center, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Abstract

The cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction pathway is critical in innate immunity, infection, and inflammation. In response to pathogenic microbial infections and other conditions, cyclic GMP-AMP synthase (cGAS) recognizes abnormal DNA and initiates a downstream type I interferon response. This paper reviews the pathogenic mechanisms of stimulator of interferon genes (STING) in different organs, including changes in fibrosis-related biomarkers, intending to systematically investigate the effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction in inflammation and fibrosis processes. The effects of stimulator of interferon genes in related auto-inflammatory and neurodegenerative diseases are described in this article, in addition to the application of stimulator of interferon genes-related drugs in treating fibrosis.

Keywords: cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway; inflammation; innate immunity; organ fibrosis; remodeling.

Publication types

Review