Advances in extraction methods, chemical constituents, pharmacological activities, molecular targets and toxicology of volatile oil from Acorus calamus var. angustatus Besser

Daoming Bai; Xiaoyu Li; Shengguang Wang; Tianyi Zhang; Yumin Wei; Qingquan Wang; Weichao Dong; Jing Song; Peng Gao; Yanan Li; Shaoping Wang; Long Dai

doi:10.3389/fphar.2022.1004529

Advances in extraction methods, chemical constituents, pharmacological activities, molecular targets and toxicology of volatile oil from Acorus calamus var. angustatus Besser

Front Pharmacol. 2022 Dec 1:13:1004529. doi: 10.3389/fphar.2022.1004529. eCollection 2022.

Authors

Daoming Bai^{1

2}, Xiaoyu Li^{1

2}, Shengguang Wang², Tianyi Zhang², Yumin Wei^{1

2}, Qingquan Wang^{1

2}, Weichao Dong^{1

2}, Jing Song³, Peng Gao², Yanan Li², Shaoping Wang¹, Long Dai¹

Affiliations

¹ School of Pharmacy, Binzhou Medical University, Yantai, China.
² School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
³ Shandong Yuze Pharmaceutical Industry Technology Research Institute Co., Ltd, Dezhou, China.

Abstract

Acorus calamus var. angustatus Besser (ATT) is a traditional herb with a long medicinal history. The volatile oil of ATT (VOA) does possess many pharmacological activities. It can restore the vitality of the brain, nervous system and myocardial cells. It is used to treat various central system, cardiovascular and cerebrovascular diseases. It also showed antibacterial and antioxidant activity. Many studies have explored the benefits of VOA scientifically. This paper reviews the extraction methods, chemical components, pharmacological activities and toxicology of VOA. The molecular mechanism of VOA was elucidated. This paper will serve as a comprehensive resource for further carrying the VOA on improving its medicinal value and clinical use.

Keywords: Acorus calamus var. angustatus Besser; chemical constituents; extraction; pharmacological activity; toxicology; volatile oil.

Publication types

Review