Diffusion-weighted imaging-based radiomics in epithelial ovarian tumors: Assessment of histologic subtype

Yi Xu; Hong-Jian Luo; Jialiang Ren; Li-Mei Guo; Jinliang Niu; Xiaoli Song

doi:10.3389/fonc.2022.978123

Diffusion-weighted imaging-based radiomics in epithelial ovarian tumors: Assessment of histologic subtype

Front Oncol. 2022 Dec 5:12:978123. doi: 10.3389/fonc.2022.978123. eCollection 2022.

Authors

Yi Xu¹, Hong-Jian Luo², Jialiang Ren³, Li-Mei Guo¹, Jinliang Niu¹, Xiaoli Song¹

Affiliations

¹ Department of Radiology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
² Department of Radiology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
³ GE Healthcare, Beijing, China.

Abstract

Background: Epithelial ovarian tumors (EOTs) are a group of heterogeneous neoplasms. It is importance to preoperatively differentiate the histologic subtypes of EOTs. Our study aims to investigate the potential of radiomics signatures based on diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps for categorizing EOTs.

Methods: This retrospectively enrolled 146 EOTs patients [34 with borderline EOT(BEOT), 30 with type I and 82 with type II epithelial ovarian cancer (EOC)]. A total of 390 radiomics features were extracted from DWI and ADC maps. Subsequently, the LASSO algorithm was used to reduce the feature dimensions. A radiomics signature was established using multivariable logistic regression method with 3-fold cross-validation and repeated 50 times. Patients with bilateral lesions were included in the validation cohort and a heuristic selection method was established to select the tumor with maximum probability for final consideration. A nomogram incorporating the radiomics signature and clinical characteristics was also developed. Receiver operator characteristic, decision curve analysis (DCA), and net reclassification index (NRI) were applied to compare the diagnostic performance and clinical net benefit of predictive model.

Results: For distinguishing BEOT from EOC, the radiomics signature and nomogram showed more favorable discrimination than the clinical model (0.915 vs. 0.852 and 0.954 vs. 0.852, respectively) in the training cohort. In classifying early-stage type I and type II EOC, the radiomics signature exhibited superior diagnostic performance over the clinical model (AUC 0.905 vs. 0.735). The diagnostic efficacy of the nomogram was the same as that of the radiomics model with NRI value of -0.1591 (P = 0.7268). DCA also showed that the radiomics model and combined model had higher net benefits than the clinical model.

Conclusion: Radiomics analysis based on DWI, and ADC maps serve as an effective quantitative approach to categorize EOTs.

Keywords: apparent diffusion coefficient; diffusion weighted imaging; epithelial ovarian tumors; nomogram; radiomics.