Oligoclonal IgM bands are a promising biomarker for long-term cognitive outcomes in multiple sclerosis

Mult Scler Relat Disord. 2022 Dec:68:104397. doi: 10.1016/j.msard.2022.104397. Epub 2022 Nov 4.

Abstract

Background: The presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid is associated with a more severe clinical multiple sclerosis (MS) course.

Objective: To investigate LS-OCMB as a prognostic biomarker of cognitive long-term outcomes in MS.

Methods: Ninety-nine patients underwent neuropsychological assessment. Cognitive performance between LS-OCMB- and LS-OCMB+ patients was compared adjusting by age, education, anxiety-depression, disease duration, and disability.

Results: LS-OCMB+ patients of ∼13 years of disease duration performed worse on Symbol Digit Modalities Test (SDMT) (p = 0.005).

Conclusion: LS-OCMB+ perform worse on information processing speed and working memory (SDMT), suggesting that LS-OCMB could be a useful biomarker for long-term cognitive outcomes.

Keywords: Biomarker; Cognition; Cognitive impairment; Lipid-specific oligoclonal IgM bands; Multiple sclerosis.

MeSH terms

  • Cognition
  • Humans
  • Immunoglobulin M
  • Multiple Sclerosis* / cerebrospinal fluid
  • Multiple Sclerosis* / complications
  • Multiple Sclerosis* / diagnosis
  • Neuropsychological Tests
  • Oligoclonal Bands / cerebrospinal fluid

Substances

  • Oligoclonal Bands
  • Immunoglobulin M