Cortico-cortical drive in a coupled premotor-primary motor cortex dynamical system

Raina D'Aleo; Adam G Rouse; Marc H Schieber; Sridevi V Sarma

doi:10.1016/j.celrep.2022.111849

Cortico-cortical drive in a coupled premotor-primary motor cortex dynamical system

Cell Rep. 2022 Dec 20;41(12):111849. doi: 10.1016/j.celrep.2022.111849.

Authors

Raina D'Aleo¹, Adam G Rouse², Marc H Schieber³, Sridevi V Sarma⁴

Affiliations

¹ Department of Neuroscience, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: rdaleo1@alumni.jh.edu.
² Department of Neurosurgery, University of Kansas, Kansas City, KS 66160, USA.
³ Department of Neuroscience, University of Rochester, Rochester, NY 14642, USA; Department of Neurology, University of Rochester, Rochester, NY 14642, USA.
⁴ Institute for Computational Medicine, Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: ssarma2@jhu.edu.

PMID: 36543147
DOI: 10.1016/j.celrep.2022.111849

Abstract

In the conventional view of sensorimotor control, the premotor cortex (PM) plans actions that are executed by the primary motor cortex (M1). This notion arises in part from many experiments that have imposed a preparatory "planning" period, during which PM becomes active without M1. But during many natural movements, PM and M1 are co-activated, making it difficult to distinguish their functional roles. We leverage coupled dynamical systems models (cDSMs) to uncover interactions between PM and M1 during movements performed with no preparatory period. We build cDSMs using neural and behavioral data recorded from two non-human primates as they performed a reach-grasp-manipulate task. PM and M1 interact dynamically throughout these movements. Whereas PM drives the M1 in some situations, in other situations, M1 drives PM activity, contrary to the conventional assumption. Our DSM framework provides additional predictions differentiating the roles of PM and M1 in controlling movement.

Keywords: CP: Neuroscience; dynamical systems model; motor control; non-human primate; premotor cortex; primary motor cortex; reach to grasp.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Hand Strength
Motor Cortex*
Movement
Psychomotor Performance

Abstract

Publication types

MeSH terms

Grants and funding