Glomerulonephritis Secondary to Acute Promyelocytic Leukemia that Resolved after Induction Therapy

Acta Haematol. 2023;146(3):240-244. doi: 10.1159/000528088. Epub 2022 Dec 20.

Abstract

The association of glomerulonephritis and malignant hematological disease is uncommon, but well known in chronic leukemias, lymphomas, and monoclonal gammopathies. However, only a few cases of glomerulonephritis and acute myeloid leukemia have been reported in the literature. We describe the first case of a genetically diagnosed acute promyelocytic leukemia presenting with nephrotic range proteinuria that resolved with induction therapy with ATRA and ATO and performed a comprehensive review of the literature.

Keywords: Acute myeloid leukemia; Acute promyelocytic leukemia; Nephrotic syndrome.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Arsenicals* / therapeutic use
  • Glomerulonephritis* / diagnosis
  • Glomerulonephritis* / drug therapy
  • Glomerulonephritis* / etiology
  • Humans
  • Induction Chemotherapy
  • Leukemia, Promyelocytic, Acute* / complications
  • Leukemia, Promyelocytic, Acute* / diagnosis
  • Leukemia, Promyelocytic, Acute* / drug therapy
  • Oxides / therapeutic use
  • Tretinoin / therapeutic use

Substances

  • Tretinoin
  • Oxides
  • Arsenicals