EMP1-positive cells found guilty of metastatic relapse in colorectal cancer

Ana Gvozdenovic; Nicola Aceto

doi:10.1016/j.devcel.2022.11.017

EMP1-positive cells found guilty of metastatic relapse in colorectal cancer

Dev Cell. 2022 Dec 19;57(24):2673-2674. doi: 10.1016/j.devcel.2022.11.017.

Authors

Ana Gvozdenovic¹, Nicola Aceto²

Affiliations

¹ Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology Zurich (ETH Zurich), Zurich, Switzerland.
² Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology Zurich (ETH Zurich), Zurich, Switzerland. Electronic address: nicola.aceto@biol.ethz.ch.

PMID: 36538891
DOI: 10.1016/j.devcel.2022.11.017

Abstract

Metastatic recurrence develops in 30%-40% of colorectal cancer (CRC) patients in the years that follow surgical removal of the primary tumor. In a recent issue of Nature, Cañellas-Socias et al. identify a distinct population of CRC cells, marked with epithelial membrane protein 1 (EMP1), accountable for metastatic relapse.

MeSH terms

Colorectal Neoplasms* / pathology
Humans
Neoplasm Proteins* / metabolism
Receptors, Cell Surface / metabolism
Recurrence

Substances

epithelial membrane protein-1
Neoplasm Proteins
Receptors, Cell Surface