Emerging trophic activities of mesencephalic astrocyte-derived neurotrophic factor in tissue repair and regeneration

Haiyan Deng; Pingping Zhang; Xianxian Gao; Weiyi Chen; Jianing Li; Fuyan Wang; Yiyue Gu; Xin Hou

doi:10.1016/j.intimp.2022.109598

Emerging trophic activities of mesencephalic astrocyte-derived neurotrophic factor in tissue repair and regeneration

Int Immunopharmacol. 2023 Jan:114:109598. doi: 10.1016/j.intimp.2022.109598. Epub 2022 Dec 18.

Authors

Haiyan Deng¹, Pingping Zhang², Xianxian Gao¹, Weiyi Chen¹, Jianing Li¹, Fuyan Wang³, Yiyue Gu⁴, Xin Hou⁵

Affiliations

¹ School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China.
² Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei, PR China.
³ School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China; Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), Qingdao, 266000, PR China.
⁴ Department of Cardiology, Xuzhou No.1 Peoples Hospital, Xuzhou, PR China.
⁵ School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China; The Affiliated Hospital of Medical School, Ningbo University, Ningbo, PR China. Electronic address: houxin@nbu.edu.cn.

PMID: 36538855
DOI: 10.1016/j.intimp.2022.109598

Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a soluble endoplasmic reticulum (ER) luminal protein and its expression and secretion can be induced by ER stress. Despite initially being classified as a neurotrophic factor, MANF has been demonstrated to have restorative and protective effects in many different cell types such as neurons, liver cells, retinal cells, cardiac myocytes, and pancreatic β cells. However, underlying molecular mechanisms are complex and remain incompletely understood. The aims of this review are to highlight the latest advances in the understanding of the trophic activities of MANF in tissue repair and regeneration as well as underlying molecular mechanisms. The structural motifs and immune modulation of MANF are also described. We therefore propose that MANF might be a promising therapeutic target for tissue repair.

Keywords: ER stress; Inflammation; MANF; Signaling pathway; Tissue repair.

Publication types

Review

MeSH terms

Astrocytes* / metabolism
Endoplasmic Reticulum / metabolism
Endoplasmic Reticulum Stress
Myocytes, Cardiac / metabolism
Nerve Growth Factors* / metabolism
Neurons

Substances

Nerve Growth Factors