COVID-19 is an infectious disease caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). It has various clinical presentations, ranging from mild and moderate to severe manifestations. This infection has caused disruptions worldwide, particularly for healthcare professionals, regarding the prescribing of immunosuppressive drugs for chronic autoinflammatory and autoimmune pathologies, such as pemphigus. We report three pemphigus patients who being treated with immunosuppressive therapy developed the SARS-CoV-2 infection. (SKINmed. 2022;20:428-429).