Relationship of size of corpus callosum with white matter changes in elderly population; A retrospective analytical cross-sectional study

Sadina Shrestha; Bishal Dhakal; Sachin Sapkota; Bishnu Deep Pathak; Binaya Dhakal; Saugat Mainali; Saurav Lamicchane; Nabin Simkhada; Priajan Ale Magar; Sagun Dawadi; Subash Phuyal

doi:10.1016/j.amsu.2022.104953

Relationship of size of corpus callosum with white matter changes in elderly population; A retrospective analytical cross-sectional study

Ann Med Surg (Lond). 2022 Nov 19:84:104953. doi: 10.1016/j.amsu.2022.104953. eCollection 2022 Dec.

Authors

Affiliations

¹ Upendra Devkota Memorial National Institute of Neurological and Allied Sciences, Department of Neuroradiology, Kathmandu, Nepal.
² Nepalese Army Institute of Health and Sciences, Department of Internal Medicine, Kathmandu, Nepal.
³ Maulakalika Hospital Private Limited, Chitwan, Nepal.
⁴ Jibjibe Primary Health Care Center, Rasuwa, Nepal.
⁵ Military Hospital Nepalgunj, Banke, Nepal.
⁶ Dhulikhel Hospital, Kavre, Nepal.

Abstract

Purpose: To study the relationship of size of corpus callosum with white matter changes in the elderly population.

Materials and methods: This was a retrospective analytical cross-sectional study. The relationship between the corpus callosum and white matter changes was studied using the magnetic resonance imaging technique, where white matter changes were graded based on Fazekas grading. The Spearman rank order correlation was used to assess the relationship between the size of corpus callosum and white matter changes.

Results: The whole corpus callosum (ρ = 0.165, p = 0.044) and rostrum (ρ = -0.232, p = 0.004) was significantly correlated with white matter changes based on Fazekas severity grading. Similarly, in bivariate regression analysis, white matter changes were strongly correlated with rostrum (standardized β-coefficient = -0.186, p = 0.023). While taking gender in sub-group analysis, white matter changes were significantly correlated with rostrum (ρ = -0.252, p = 0.021) and splenium (ρ = -0.229, p = 0.036) in male and with rostrum (ρ = -0.245, p = 0.048) only in female groups.

Conclusions: Corpus callosum size is associated with white matter changes in the elderly population. This association can give insight into the neuropathology of diseases involving the central nervous system.

Keywords: CC, Corpus Callosum; Corpus callosum; Correlation; Elderly; MRI, Magnetic Resonance Imaging; Magnetic resonance imaging; WMC, White Matter Changes; WMH, White Matter Hyperintensity; WML, White Matter Lesions; White matter changes; White matter hyperintensity.