Tuning chitosan's chemical structure for enhanced biological functions

Mortaza Aghbashlo; Hamid Amiri; Seyed Masoud Moosavi Basri; Hajar Rastegari; Su Shiung Lam; Junting Pan; Vijai Kumar Gupta; Meisam Tabatabaei

doi:10.1016/j.tibtech.2022.11.009

Tuning chitosan's chemical structure for enhanced biological functions

Trends Biotechnol. 2023 Jun;41(6):785-797. doi: 10.1016/j.tibtech.2022.11.009. Epub 2022 Dec 17.

Authors

Mortaza Aghbashlo¹, Hamid Amiri², Seyed Masoud Moosavi Basri³, Hajar Rastegari⁴, Su Shiung Lam⁴, Junting Pan⁵, Vijai Kumar Gupta⁶, Meisam Tabatabaei⁷

Affiliations

¹ Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Department of Mechanical Engineering of Agricultural Machinery, Faculty of Agricultural Engineering and Technology, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.
² Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan 81746-73441, Iran; Environmental Research Institute, University of Isfahan, Isfahan 81746-73441, Iran.
³ Kuwait Cancer Control Center (KCCC), Kuwait City, Kuwait.
⁴ Higher Institution Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries (AKUATROP), Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia.
⁵ Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China. Electronic address: panjunting@caas.cn.
⁶ Biorefining and Advanced Materials Research Center, SRUC, Kings Buildings, West Mains Road, Edinburgh EH9 3JG, UK; Center for Safe and Improved Food, SRUC, Kings Buildings, West Mains Road, Edinburgh EH9 3JG, UK. Electronic address: vijai.gupta@sruc.ac.uk.
⁷ Higher Institution Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries (AKUATROP), Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia. Electronic address: meisam.tabatabaei@umt.edu.my.

PMID: 36535818
DOI: 10.1016/j.tibtech.2022.11.009

Abstract

Chitosan, an amino polysaccharide mostly derived from crustaceans, has been recently highlighted for its biological activities that depend on its molecular weight (MW), degree of deacetylation (DD), and acetylation pattern (AP). More importantly, for some advanced biomaterials, the homogeneity of the chitosan structure is an important factor in determining its biological activity. Here we review emerging enzymes and cell factories, respectively, for in vitro and in vivo preparation of chitosan oligosaccharides (COSs), focusing on advances in the analysis of the AP and structural modification of chitosan to tune its functions. By 'mapping' current knowledge on chitosan's in vitro and in vivo activity with its MW and AP, this work could pave the way for future studies in the field.

Keywords: acetylation pattern; biological activity; chitosan; homogeneity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry
Chitosan* / chemistry

Substances

Chitosan
Biocompatible Materials