The role of extracellular ATP in homeostatic immune cell migration

Daichi Kobayashi; Eiji Umemoto; Masayuki Miyasaka

doi:10.1016/j.coph.2022.102331

The role of extracellular ATP in homeostatic immune cell migration

Curr Opin Pharmacol. 2023 Feb:68:102331. doi: 10.1016/j.coph.2022.102331. Epub 2022 Dec 17.

Authors

Daichi Kobayashi¹, Eiji Umemoto², Masayuki Miyasaka³

Affiliations

¹ Department of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
² Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
³ Immunology Frontier Research Center, Osaka University, Suita, Japan. Electronic address: masayukimiyasaka@ifrec.osaka-u.ac.jp.

PMID: 36535235
DOI: 10.1016/j.coph.2022.102331

Abstract

Antigen stimulation induces adenosine triphosphate (ATP) release from naïve lymphocytes in lymphoid tissues. However, previous studies indicated that the non-lytic release of ATP also occurs in most tissues and cell types under physiological conditions. Here, we show that extracellular ATP (eATP) is indeed constitutively produced by naïve T cells in response to lymphoid chemokines in uninflamed lymph nodes and is involved in the regulation of immune cell migration. In this review, we briefly summarize the homeostatic role of extracellular ATP in immune cell migration in vivo.

Keywords: ATP; Cell migration; Chemokine; Lymphocyte; Purinergic receptor.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate* / metabolism
Cell Movement
Humans
Lymph Nodes / metabolism
T-Lymphocytes*

Substances

Adenosine Triphosphate