Simultaneous CSM-TACE with CalliSpheres® and partial splenic embolization using 8spheres® for hepatocellular carcinoma with hypersplenism: Early prospective multicenter clinical outcome

Jun Zhou; Zhuo Feng; Song Liu; Xiang Li; Ying Liu; Fei Gao; Jing Shen; Yue Wei Zhang; Guang Sheng Zhao; Ming Zhang

doi:10.3389/fonc.2022.998500

Simultaneous CSM-TACE with CalliSpheres^® and partial splenic embolization using 8spheres^® for hepatocellular carcinoma with hypersplenism: Early prospective multicenter clinical outcome

Front Oncol. 2022 Dec 1:12:998500. doi: 10.3389/fonc.2022.998500. eCollection 2022.

Authors

Jun Zhou^{1

2}, Zhuo Feng³, Song Liu⁴, Xiang Li², Ying Liu⁵, Fei Gao⁶, Jing Shen⁷, Yue Wei Zhang⁵, Guang Sheng Zhao², Ming Zhang¹

Affiliations

¹ Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
² Minimally Invasive Interventional Diagnosis and Treatment Center, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
³ Department of Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
⁴ Cancer Interventional Center, Linyi Cancer Hospital, Linyi, Shandong, China.
⁵ Hepatobiliary and Pancreatic Center, Beijing Tsinghua Changgung Hospital, Beijing, China.
⁶ Cancer Interventional Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
⁷ Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.

Abstract

Background: Primary hepatocellular carcinoma is often complicated with hepatitis and liver cirrhosis. Some patients develop different degrees of splenomegaly, hypersplenism and hypohepatia due to the aggravation of liver cirrhosis, which to some extent interfere with the treatment of tumors and even affect the prognosis of patients. In this study, we prospectively evaluate the efficacy and safety of simultaneous CalliSpheres^® microspheres transcatheter arterial chemoembolization (CSM-TACE) and partial splenic embolization (PSE) using 8spheres^® for hepatocellular carcinoma (HCC) with hypersplenism.

Methods: Ninety consecutive HCC patients with hypersplenism who underwent CSM-TACE were selected: 32 patients in CSM-TACE+PSE group, and 58 patients in CSM-TACE group. The peripheral blood cell counts (leukocyte, platelet (PLT), liver function and red blood cell (RBC)), CSM-TACE and/or PSE related complications, and the tumor control rate at 1 month after CSM-TACE were compared. The survival time and prognostic factors were also observed.

Results: Before CSM-TACE, there were no significant differences in sex, age, Child-Pugh grade, tumor size, and alpha-fetoprotein (AFP) between the two groups. After CSM-TACE, the PLT and white blood cell (WBC) counts in CSM-TACE+PSE group were significantly higher than those in the CSM-TACE group (P<0.05). There were no significant differences in RBC before and after treatment (P > 0.05). In the CSM-TACE group, there were no significant differences in WBC, PLT, and RBC before and after treatment (P > 0.05). There was no significant difference in liver function at 1 month after treatment between the two groups. The cholinesterase (CHE) level in the CSM-TACE+PSE group after CSM-TACE+PSE was obviously higher than that before CSM-TACE+PSE and higher than that in the CSM-TACE group (P<0.05). However, the level of CHE returned to the preoperative level 1 month after CSM-TACE in the CSM-TACE group. The objective response rate (ORR) and median overall survival (OS) in the CSM-TACE+PSE group were higher than those in the CSM-TACE group (P<0.05). The adverse reactions of the two groups were fever, abdominal pain, stomach discomfort, nausea, and vomiting, and no serious complications occurred. The degree of abdominal pain and fever in the experimental group was lower than that in the control group (P > 0.05).

Conclusions: Simultaneous CSM-TACE and PSE using domestic embolization particles for HCC with hypersplenism have good safety and efficacy and has a low incidence of PSE-related adverse events, it is conducive to improving liver function reserve, and can further improve the median OS.

Keywords: 8spheres®; CSM-TACE; calliSpheres®; hepatocellular carcinoma; hypersplenism; partial splenic embolization.