Synthesis of Novel Pyrimido[4,5- b] Quinolines Containing Benzyloxy and 1,2,3-Triazole Moieties by DABCO as a Basic Catalyst

Soheila Esmaili; Ahmad Reza Moosavi-Zare; Ardeshir Khazaei; Zahra Najafi

doi:10.1021/acsomega.2c05896

Synthesis of Novel Pyrimido[4,5- b] Quinolines Containing Benzyloxy and 1,2,3-Triazole Moieties by DABCO as a Basic Catalyst

ACS Omega. 2022 Dec 2;7(49):45314-45324. doi: 10.1021/acsomega.2c05896. eCollection 2022 Dec 13.

Authors

Soheila Esmaili¹, Ahmad Reza Moosavi-Zare², Ardeshir Khazaei¹, Zahra Najafi³

Affiliations

¹ Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran.
² Department of Chemical Engineering, Hamedan University of Technology, Hamedan 65155, Iran.
³ Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan 6517838678, Iran.

Abstract

DABCO was used as a basic and inexpensive catalyst for the synthesis of some new benzyloxy pyrimido[4,5-b]quinoline derivatives and 1,2,3- triazole-fused pyrimido[4,5-b]quinolines by the one-pot multi-component reaction of various benzyloxy benzaldehydes or benzylic -1,2,3-triazol-4-yl-methoxy benzaldehydes with dimedone and 6-amino-1,3-dimethyluracil at 90 °C under the solvent-free condition.