Indium chloride catalysed benzyl bromination using continuous flow technology

Org Biomol Chem. 2023 Jan 18;21(3):508-513. doi: 10.1039/d2ob01840c.

Abstract

This report describes the development of a water-tolerant green catalyst for benzyl bromination. The catalyst, indium chloride, exhibits high catalytic activity with a variety of toluene derivatives in continuous flow. Good yields (59-77%) were obtained in all the cases. Improved selectivity was observed under flow conditions, when compared to batch operation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Halogenation*
  • Indium
  • Toluene*
  • Water

Substances

  • indium trichloride
  • Toluene
  • Indium
  • Water