Mapping the landscape of lung cancer breath analysis: A scoping review (ELCABA)

Felix Schmidt; Dario Kohlbrenner; Stefan Malesevic; Alice Huang; Sabine D Klein; Milo A Puhan; Malcolm Kohler

doi:10.1016/j.lungcan.2022.12.003

Mapping the landscape of lung cancer breath analysis: A scoping review (ELCABA)

Lung Cancer. 2023 Jan:175:131-140. doi: 10.1016/j.lungcan.2022.12.003. Epub 2022 Dec 12.

Authors

Felix Schmidt¹, Dario Kohlbrenner², Stefan Malesevic², Alice Huang³, Sabine D Klein⁴, Milo A Puhan⁵, Malcolm Kohler⁶

Affiliations

¹ University of Zurich, Faculty of Medicine, Zurich, Switzerland; University Hospital Zurich, Department of Pulmonology, Zurich, Switzerland. Electronic address: felix.schmidt@usz.ch.
² University of Zurich, Faculty of Medicine, Zurich, Switzerland; University Hospital Zurich, Department of Pulmonology, Zurich, Switzerland.
³ University Hospital Zurich, Department of Medical Oncology and Hematology, Zurich, Switzerland.
⁴ University of Zurich, University Library, Zurich, Switzerland.
⁵ University of Zurich, Epidemiology, Biostatistics and Prevention Institute, Zurich, Switzerland.
⁶ University of Zurich, Faculty of Medicine, Zurich, Switzerland; University Hospital Zurich, Department of Pulmonology, Zurich, Switzerland; University of Zurich, Zurich Centre for Integrative Human Physiology, Zurich, Switzerland.

PMID: 36529115
DOI: 10.1016/j.lungcan.2022.12.003

Abstract

Lung cancer is the leading cause of cancer death worldwide due to its late-stage detection. Lung cancer screening, including low-dose computed tomography (low-dose CT), provides an initial clinical solution. Nevertheless, further innovations and refinements would help to alleviate remaining limitations. The non-invasive, gentle, and fast nature of breath analysis (BA) makes this technology highly attractive to supplement low-dose CT for an improved screening algorithm. However, BA has not taken hold in everyday clinical practice. One reason might be the heterogeneity and variety of BA methods. This scoping review is a comprehensive summary of study designs, breath analytical methods, and suggested biomarkers in lung cancer. Furthermore, this synthesis provides a framework with core outcomes for future studies in lung cancer BA. This work supports future research for evidence synthesis, meta-analysis, and translation into clinical routine workflows.

Keywords: Biomarker; Breath; Detection; Lung cancer; Scoping review; Screening.

Publication types

Meta-Analysis
Review

MeSH terms

Biomarkers
Early Detection of Cancer / methods
Humans
Lung Neoplasms* / diagnosis
Tomography, X-Ray Computed

Substances

Biomarkers