Mechanism and application of ferroptosis in colorectal cancer

Liu Yang; Yewei Zhang; Yingyi Zhang; Zhe Fan

doi:10.1016/j.biopha.2022.114102

Mechanism and application of ferroptosis in colorectal cancer

Biomed Pharmacother. 2023 Feb:158:114102. doi: 10.1016/j.biopha.2022.114102. Epub 2022 Dec 16.

Authors

Liu Yang¹, Yewei Zhang², Yingyi Zhang³, Zhe Fan⁴

Affiliations

¹ Department of General Surgery, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China; Department of Central Laboratory, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China; Liaoning Province Key Laboratory of Corneal and Ocular Surface Diseases Research, The Third People's Hospital of Dalian, Dalian, China.
² Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: zhangyewei@njmu.edu.cn.
³ Department of General Surgery, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China; Department of Central Laboratory, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China; Liaoning Province Key Laboratory of Corneal and Ocular Surface Diseases Research, The Third People's Hospital of Dalian, Dalian, China. Electronic address: zhangyingyidl@outlook.com.
⁴ Department of General Surgery, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China; Department of Central Laboratory, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China; Liaoning Province Key Laboratory of Corneal and Ocular Surface Diseases Research, The Third People's Hospital of Dalian, Dalian, China. Electronic address: fanzhe1982@hotmail.com.

PMID: 36528917
DOI: 10.1016/j.biopha.2022.114102

Abstract

Colorectal cancer (CRC) is the third most common malignant tumor in the world. CRC has high morbidity and mortality rates and it is a serious threat to human health. Ferroptosis is a unique form of iron-dependent oxidative cell death that is usually accompanied by iron accumulation and lipid peroxidation. Ferroptosis has attracted worldwide attention since it was first proposed. It plays an important role in the development of a variety of diseases, such as tumors, ischemia/reperfusion injury, nervous system diseases, and kidney damage, and it may serve as a new therapeutic target. This article reviews the mechanism of ferroptosis and the possibility to target ferroptosis pathways in CRC, providing new ideas for the diagnosis and treatment of CRC.

Keywords: CRC; Ferroptosis; GSH; ROS; Signaling pathway.

Publication types

Review

MeSH terms

Cell Death
Colorectal Neoplasms*
Ferroptosis*
Humans
Iron
Lipid Peroxidation

Substances

Iron