Gut microbiota and colorectal cancer metastasis

Zongmei Zheng; Xinxin Hou; Zhaoxiang Bian; Wei Jia; Ling Zhao

doi:10.1016/j.canlet.2022.216039

Gut microbiota and colorectal cancer metastasis

Cancer Lett. 2023 Feb 28:555:216039. doi: 10.1016/j.canlet.2022.216039. Epub 2022 Dec 15.

Authors

Zongmei Zheng¹, Xinxin Hou¹, Zhaoxiang Bian², Wei Jia³, Ling Zhao⁴

Affiliations

¹ Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
³ School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China; Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address: weijia1@hkbu.edu.hk.
⁴ Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: lzhao@shutcm.edu.cn.

PMID: 36528182
DOI: 10.1016/j.canlet.2022.216039

Abstract

Gut microbiota play critical roles in the development of colorectal cancer (CRC) metastasis, but the underlying mechanisms remain elusive. This review discusses the molecular mechanisms by which the gut microbiota contribute to a tumor-permissive microenvironment and facilitate malignant transformation and dissemination of tumor cells, thereby mediating CRC metastasis.

Keywords: Colorectal cancer; Gut microbiota; Metastasis; Tumor microenvironment.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / pathology
Gastrointestinal Microbiome*
Humans
Tumor Microenvironment