Pulmonary Embolism in COVID-19 Patients Is Not Related to a Deterioration of Tissue Oxygenation

Sebastiano Cicco; F Albanese; R Didonna; A Magistro; A Vacca; C Cariddi; G Lauletta; F Pappagallo; A G Solimando; R Ria

doi:10.1007/978-3-031-14190-4_17

Pulmonary Embolism in COVID-19 Patients Is Not Related to a Deterioration of Tissue Oxygenation

Adv Exp Med Biol. 2022:1395:99-103. doi: 10.1007/978-3-031-14190-4_17.

Authors

Sebastiano Cicco¹, F Albanese¹, R Didonna¹, A Magistro¹, A Vacca², C Cariddi³, G Lauletta¹, F Pappagallo¹, A G Solimando¹, R Ria¹

Affiliations

¹ COVID Section, Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari, University Hospital Policlinico di Bari, Bari, Italy.
² Division of Internal Medicine, Department of Medicine, Building 8, University of Udine, Udine (UD), Italy.
³ Dipartimento dell'Emergenza e Trapianti d'Organo (DETO), Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, University of Bari Aldo Moro, Bari, Italy.

PMID: 36527621
DOI: 10.1007/978-3-031-14190-4_17

Abstract

Background: COVID-19 induces robust systemic inflammation. One of the main complications is the increased coagulation due to endotheliitis. There is an increased incidence of pulmonary embolism (PE) in COVID-19 patients. However, clinical characteristics for a strict analysis are yet to be determined.

Aim: We evaluated oxygenation and characteristics in patients with COVID-19 PE (CPE).

Material and methods: We evaluated 215 COVID-19 patients from 1 January to 30 April 2021. We found 18 patients affected by PE (CPE, 50.0% males, aged 67.00 ± 10.86 years). As controls, we used data from patients affected by PE evaluated in our ward between 1 January 2015 and 31 December 2019 (64 patients, 53.1% males, aged 70.88 ± 16.44 years). All patients underwent a complete physical examination, pulmonary computerised tomography, laboratory tests, D-dimers and blood gas analysis at the time of diagnosis.

Results: There were no differences in laboratory tests nor in D-dimers between the two groups. In the CPE group we found a significantly increased pO₂ (92.83 ± 42.52 vs. 76.11 ± 32.58 mmHg; p < 0.05), difference of oxygen between alveoli and arteries (A-aDO₂; 169.3 ± 171.9 vs. 52.97 ± 39.65 mmHg; p < 0.05), and oxygen saturation % (97.06 ± 2.59 vs. 93.77 ± 5.53%; p < 0.05) compared to controls. No difference was found in pCO₂ and the ratio between pO₂ and percentage of inspired oxygen (P/F). Finally, a significantly decreased urate (3.67 ± 1.49 vs. 5.60 ± 2.10; p < 0.05) was found in CPE compared to controls. In CPE, platelets count presents an inverse correlation to P/F (r = -0.389, p = 0.02) but a direct correlation to A-aDO₂ (r = 0.699, p = 0.001). No similar findings were present in controls.

Discussion: COVID-19 PE appears to have a different clinical setting. Reduced oxygenation described in PE may not to be considered as a sign of disease. The increased A-aDO₂ may indicate that COVID-19 PE involved smaller vessels compared to classical PE. A possible diffuse capillary thrombosis could explain these results.

Keywords: Endotheliitis; Platelet counts; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2); Systemic inflammation.

MeSH terms

COVID-19* / complications
Female
Humans
Male
Oxygen
Pulmonary Embolism* / diagnosis
Pulmonary Embolism* / etiology
Retrospective Studies
Thrombosis* / complications

Substances

Oxygen