New meroterpenoids from a soil-derived fungus Penicillium sp. SSW03M2 GY and their anti-virulence activity

Hyeri Ku; Yeonhee Lee; Seungjin Lee; Jin Woo Lee; Hahk-Soo Kang; Hwang-Soo Joo; Sang Hee Shim

doi:10.1038/s41429-022-00587-7

New meroterpenoids from a soil-derived fungus Penicillium sp. SSW03M2 GY and their anti-virulence activity

J Antibiot (Tokyo). 2023 Feb;76(2):57-64. doi: 10.1038/s41429-022-00587-7. Epub 2022 Dec 16.

Authors

Hyeri Ku¹, Yeonhee Lee², Seungjin Lee¹, Jin Woo Lee³, Hahk-Soo Kang⁴, Hwang-Soo Joo², Sang Hee Shim⁵

Affiliations

¹ Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
² College of Science and Technology, Duksung Women's University, Seoul, Republic of Korea.
³ College of Pharmacy, Duksung Women's University, Seoul, Republic of Korea.
⁴ Department of Biomedical Science and Engineering, Konkuk University, Seoul, Republic of Korea.
⁵ Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea. sanghee_shim@snu.ac.kr.

PMID: 36526742
DOI: 10.1038/s41429-022-00587-7

Abstract

Two new berkeley meroterpenoids (1 and 2), along with seven known compounds (3‒9) were isolated from a fungus, Penicillium sp. SSW03M2 GY derived from a sediment at Seosan bay, South Korea. Chemical structures of the isolated compounds were elucidated on the basis of 1D, 2D NMR, HRESIMS, and optical rotation. All the isolated compounds, 1 showed anti-virulence activity by significantly inhibiting α-toxin (Hla) secreted by methicillin-resistant Staphylococcus aureus without its growth inhibition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Magnetic Resonance Spectroscopy
Methicillin-Resistant Staphylococcus aureus*
Molecular Structure
Penicillium* / chemistry
Republic of Korea